Publication Date:
2007-08-19
Description:
Aneuploidy is a condition frequently found in tumor cells, but its effect on cellular physiology is not known. We have characterized one aspect of aneuploidy: the gain of extra chromosomes. We created a collection of haploid yeast strains that each bear an extra copy of one or more of almost all of the yeast chromosomes. Their characterization revealed that aneuploid strains share a number of phenotypes, including defects in cell cycle progression, increased glucose uptake, and increased sensitivity to conditions interfering with protein synthesis and protein folding. These phenotypes were observed only in strains carrying additional yeast genes, which indicates that they reflect the consequences of additional protein production as well as the resulting imbalances in cellular protein composition. We conclude that aneuploidy causes not only a proliferative disadvantage but also a set of phenotypes that is independent of the identity of the individual extra chromosomes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Torres, Eduardo M -- Sokolsky, Tanya -- Tucker, Cheryl M -- Chan, Leon Y -- Boselli, Monica -- Dunham, Maitreya J -- Amon, Angelika -- GM071508/GM/NIGMS NIH HHS/ -- GM56800/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2007 Aug 17;317(5840):916-24.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Center for Cancer Research, Howard Hughes Medical Institute, Massachusetts Institute of Technology, E17-233, 40 Ames Street, Cambridge, MA 02139, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17702937" target="_blank"〉PubMed〈/a〉
Keywords:
*Aneuploidy
;
Cell Division
;
*Cell Proliferation
;
Chromosomes, Fungal/genetics
;
G1 Phase
;
Gene Expression Regulation, Fungal
;
Genes, Fungal
;
Glucose/metabolism
;
Haploidy
;
Phenotype
;
Protein Synthesis Inhibitors/pharmacology
;
Saccharomyces cerevisiae/cytology/*genetics/*physiology
;
Saccharomyces cerevisiae Proteins/biosynthesis/metabolism
;
Temperature
;
Transcription, Genetic
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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