ISSN:
1573-4919
Keywords:
heart failure
;
adrenergic receptor
;
muscarinic receptor
;
G-protein
;
phosphodiesterase inhibitor
;
angiotensin converting enzyme inhibitor
;
β-adrenoceptor antagonist
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Chemistry and Pharmacology
,
Medicine
Notes:
Abstract In end-stage heart failure the expression of different myocardial regulatory proteins involved in the β-adrenergic cAMP signalling pathway is altered. The downregulation of β-adrenoceptors and their uncoupling from the effector as well as an increased expression of the inhibitory GTP-binding protein seem to be the most important alterations. Since catecholamine levels are elevated in these patients and since some alterations can be ‘restored’ after treatment with β-adrenoceptor antagonists it was hypothesized that excessive β-adrenergic stimulation could be involved in these alterations. In this article the changes of β-adrenergic receptors, GTP-binding proteins, sarcoplasmic reticulum Ca2+-ATPase and of phospholamban found in heart failure are addressed with its possible therapeutic implications.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00227907
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