ALBERT

All Library Books, journals and Electronic Records Telegrafenberg

feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    ISSN: 0170-2041
    Keywords: Fucopyranosyl phosphate ; Fucose 1-phosphate ; Glycosyl phosphate ; GDP-fucose ; Guanosine diphosphofucose ; Trichloroacetimidates ; Carbohydrates ; Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Reaction of the benzyl- and acetyl-protected α-trichloroacetimidates 1 and 6α with dialkyl and diaryl phosphates in the presence of traces of acid affords stereoelectively the thermodynamically more stable α-L-fucopyranosyl phosphates 2, 7 and 8, respectively, in high yields. The use of very pure, recrystallized dibenzyl phosphate results in the stereoeletive formation of the β-L-fucopyranosyl phosphates 3 and 9. In each case separation of the anomers is not required because of the very high stereoselectivity of the reactions. After deprotection the fucose 1-phosphate 12 is coupled with GMP morpholidate 10 to yield GDP-fucose 13. After the development of a new purification procedure for GDP-fucose 13 we have obtained a very pure compound suitable for biochemical investigations. Analytical and preparative HPLC has been performed on reversed-phase columns using a volatile buffer system (triethylammonium hydrogen carbonate) as the eluant.
    Type of Medium: Electronic Resource
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...