Publication Date:
2007-01-27
Description:
The normal synovium forms a membrane at the edges of joints and provides lubrication and nutrients for the cartilage. In rheumatoid arthritis, the synovium is the site of inflammation, and it participates in an organized tissue response that damages cartilage and bone. We identified cadherin-11 as essential for the development of the synovium. Cadherin-11-deficient mice have a hypoplastic synovial lining, display a disorganized synovial reaction to inflammation, and are resistant to inflammatory arthritis. Cadherin-11 therapeutics prevent and reduce arthritis in mouse models. Thus, synovial cadherin-11 determines the behavior of synovial cells in their proinflammatory and destructive tissue response in inflammatory arthritis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lee, David M -- Kiener, Hans P -- Agarwal, Sandeep K -- Noss, Erika H -- Watts, Gerald F M -- Chisaka, Osamu -- Takeichi, Masatoshi -- Brenner, Michael B -- K08 AR2214/AR/NIAMS NIH HHS/ -- R01 AR48114/AR/NIAMS NIH HHS/ -- New York, N.Y. -- Science. 2007 Feb 16;315(5814):1006-10. Epub 2007 Jan 25.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Medicine and Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, 1 Jimmy Fund Way, Boston, MA 02115, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17255475" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Antibodies, Monoclonal/therapeutic use
;
Arthritis, Experimental
;
Arthritis, Rheumatoid/metabolism/*pathology/therapy
;
Cadherins/*antagonists & inhibitors/biosynthesis/deficiency/*physiology
;
Cell Adhesion/physiology
;
Disease Models, Animal
;
Extracellular Matrix/metabolism
;
Fibroblasts/metabolism
;
L Cells (Cell Line)
;
Male
;
Mice
;
Mice, Inbred C57BL
;
Organ Culture Techniques
;
Synovial Membrane/*cytology/*pathology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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