Publication Date:
1985-08-23
Description:
A specific fibrinolytic agent was synthesized by covalently coupling urokinase to a monoclonal antibody that was fibrin-specific and did not cross-react with fibrinogen. The antibody was raised against a synthetic peptide representing the seven amino-terminal residues of the beta chain of human fibrin. The urokinase-antifibrin conjugate retained the original binding specificity of the antibody and showed 100-fold increased fibrinolysis in vitro when compared to unmodified urokinase. The presence of human fibrinogen at plasma concentration did not influence these properties.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bode, C -- Matsueda, G R -- Hui, K Y -- Haber, E -- New York, N.Y. -- Science. 1985 Aug 23;229(4715):765-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/4023710" target="_blank"〉PubMed〈/a〉
Keywords:
Antibodies, Monoclonal/*therapeutic use
;
Cross-Linking Reagents
;
Fibrin/immunology
;
*Fibrinolysis
;
Humans
;
In Vitro Techniques
;
Kinetics
;
Structure-Activity Relationship
;
Urokinase-Type Plasminogen Activator/*administration & dosage
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
Permalink
