Publication Date:
2006-06-03
Description:
The human intestinal microbiota is composed of 10(13) to 10(14) microorganisms whose collective genome ("microbiome") contains at least 100 times as many genes as our own genome. We analyzed approximately 78 million base pairs of unique DNA sequence and 2062 polymerase chain reaction-amplified 16S ribosomal DNA sequences obtained from the fecal DNAs of two healthy adults. Using metabolic function analyses of identified genes, we compared our human genome with the average content of previously sequenced microbial genomes. Our microbiome has significantly enriched metabolism of glycans, amino acids, and xenobiotics; methanogenesis; and 2-methyl-d-erythritol 4-phosphate pathway-mediated biosynthesis of vitamins and isoprenoids. Thus, humans are superorganisms whose metabolism represents an amalgamation of microbial and human attributes.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3027896/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3027896/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gill, Steven R -- Pop, Mihai -- Deboy, Robert T -- Eckburg, Paul B -- Turnbaugh, Peter J -- Samuel, Buck S -- Gordon, Jeffrey I -- Relman, David A -- Fraser-Liggett, Claire M -- Nelson, Karen E -- AI51259/AI/NIAID NIH HHS/ -- DK70977/DK/NIDDK NIH HHS/ -- R01 AI051259/AI/NIAID NIH HHS/ -- R01 AI051259-04/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 2006 Jun 2;312(5778):1355-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA. srgill@buffalo.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16741115" target="_blank"〉PubMed〈/a〉
Keywords:
Adult
;
Bacteria/classification/*genetics/isolation & purification
;
Bifidobacterium/genetics
;
*DNA, Ribosomal
;
Dietary Carbohydrates/metabolism
;
Dietary Fiber/metabolism
;
Feces/microbiology
;
Female
;
Fermentation
;
*Genetic Variation
;
Genome, Bacterial
;
Genomics
;
Humans
;
Intestinal Mucosa/metabolism/microbiology
;
Intestines/metabolism/*microbiology
;
Male
;
Molecular Sequence Data
;
Open Reading Frames
;
Phylogeny
;
RNA, Ribosomal, 16S/genetics
;
Xenobiotics/metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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