Publication Date:
2004-01-31
Description:
It is generally accepted that paternally imprinted X inactivation occurs exclusively in extraembryonic lineages of mouse embryos, whereas cells of the embryo proper, derived from the inner cell mass (ICM), undergo only random X inactivation. Here we show that imprinted X inactivation, in fact, occurs in all cells of early embryos and that the paternal X is then selectively reactivated in cells allocated to the ICM. This contrasts with more differentiated cell types where X inactivation is highly stable and generally irreversible. Our observations illustrate that an important component of genome plasticity in early development is the capacity to reverse heritable gene silencing decisions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mak, Winifred -- Nesterova, Tatyana B -- de Napoles, Mariana -- Appanah, Ruth -- Yamanaka, Shinya -- Otte, Arie P -- Brockdorff, Neil -- New York, N.Y. -- Science. 2004 Jan 30;303(5658):666-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉X inactivation group, MRC Clinical Sciences Centre, ICSM, Hammersmith Hospital, London, W12 0NN, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/14752160" target="_blank"〉PubMed〈/a〉
Keywords:
Acetylation
;
Animals
;
Blastocyst/physiology
;
Cell Cycle Proteins/genetics/metabolism
;
Chromosomal Proteins, Non-Histone/genetics/metabolism
;
Chromosomes, Mammalian/physiology
;
*Dosage Compensation, Genetic
;
Embryo, Mammalian/*physiology
;
Embryonic and Fetal Development
;
Female
;
*Gene Expression Regulation, Developmental
;
Genomic Imprinting
;
Histones/metabolism
;
Male
;
Methylation
;
Mice
;
Mice, Inbred C57BL
;
Mice, Inbred CBA
;
Morula/physiology
;
Polycomb Repressive Complex 2
;
Proteins/genetics/metabolism
;
RNA, Long Noncoding
;
RNA, Untranslated/genetics/metabolism
;
Repressor Proteins/genetics/metabolism
;
X Chromosome/*physiology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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