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  • 1
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    Cancer chemopreventive activity of resveratrol, a natural product derived from grapes (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-01-10
    Description: Resveratrol, a phytoalexin found in grapes and other food products, was purified and shown to have cancer chemopreventive activity in assays representing three major stages of carcinogenesis. Resveratrol was found to act as an antioxidant and antimutagen and to induce phase II drug-metabolizing enzymes (anti-initiation activity); it mediated anti-inflammatory effects and inhibited cyclooxygenase and hydroperoxidase functions (antipromotion activity); and it induced human promyelocytic leukemia cell differentiation (antiprogression activity). In addition, it inhibited the development of preneoplastic lesions in carcinogen-treated mouse mammary glands in culture and inhibited tumorigenesis in a mouse skin cancer model. These data suggest that resveratrol, a common constituent of the human diet, merits investigation as a potential cancer chemopreventive agent in humans.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jang, M -- Cai, L -- Udeani, G O -- Slowing, K V -- Thomas, C F -- Beecher, C W -- Fong, H H -- Farnsworth, N R -- Kinghorn, A D -- Mehta, R G -- Moon, R C -- Pezzuto, J M -- P01 CA48112/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1997 Jan 10;275(5297):218-20.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8985016" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Anti-Inflammatory Agents, Non-Steroidal/pharmacology/therapeutic use ; Anticarcinogenic Agents/*pharmacology/therapeutic use ; Antimutagenic Agents/pharmacology ; Carcinogens ; Cell Differentiation/drug effects ; Cyclooxygenase 1 ; Cyclooxygenase Inhibitors/pharmacology/therapeutic use ; Female ; Fruit/*chemistry ; Humans ; Inflammation/drug therapy ; Isoenzymes/metabolism ; Mammary Neoplasms, Experimental/chemically induced/prevention & control ; Membrane Proteins ; Mice ; Neoplasms, Experimental/*prevention & control ; Peroxidases/antagonists & inhibitors ; Precancerous Conditions/prevention & control ; Prostaglandin-Endoperoxide Synthases/metabolism ; Rats ; Rats, Wistar ; Skin Neoplasms/chemically induced/prevention & control ; Stilbenes/*pharmacology/therapeutic use ; Tumor Cells, Cultured
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Assortative mating as a mechanism for rapid evolution of a migratory divide (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-10-22
    Description: There have been numerous recent observations of changes in the behavior and dynamics of migratory bird populations, but the plasticity of the migratory trait and our inability to track small animals over large distances have hindered investigation of the mechanisms behind migratory change. We used habitat-specific stable isotope signatures to show that recently evolved allopatric wintering populations of European blackcaps Sylvia atricapilla pair assortatively on their sympatric breeding grounds. Birds wintering further north also produce larger clutches and fledge more young. These findings describe an important process in the evolution of migratory divides, new migration routes, and wintering quarters. Temporal segregation of breeding is a way in which subpopulations of vertebrates may become isolated in sympatry.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bearhop, Stuart -- Fiedler, Wolfgang -- Furness, Robert W -- Votier, Stephen C -- Waldron, Susan -- Newton, Jason -- Bowen, Gabriel J -- Berthold, Peter -- Farnsworth, Keith -- New York, N.Y. -- Science. 2005 Oct 21;310(5747):502-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉School of Biology and Biochemistry, Medical Biological Centre, Lisburn Road, Queen's University Belfast, Belfast BT6 7BL, UK. s.bearhop@qub.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16239479" target="_blank"〉PubMed〈/a〉
    Keywords: *Animal Migration ; Animals ; *Biological Evolution ; Carbon Isotopes/analysis ; Environment ; Europe ; Female ; Hydrogen/analysis ; Isotopes ; Male ; Passeriformes/*physiology ; Regression Analysis ; *Reproduction ; Seasons ; *Sexual Behavior, Animal
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
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