Publication Date:
1978-05-19
Description:
Peripheral administration of the COOH-terminal octapeptide of cholecystokinin in doses from 1 to 100 micrograms per kilogram of body weight (0.25 to 25.0 micrograms per rat) significantly antagonized tail pinch-induced eating in rats, an animal model for stress-induced human hyperphagia. Centrally administered cholecystokinin was effective only in high doses (3 micrograms into the cerebral ventricle). The finding that the minimal effective dose of cholecystokinin in suppressing stress-induced appetitive behavior is smaller after peripheral than central administration suggests that the peptide is acting on peripheral, as opposed to central nervous system, substrates.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nemeroff, C B -- Osbahr, A J 3rd -- Bissette, G -- Jahnke, G -- Lipton, M A -- Prange, A J -- New York, N.Y. -- Science. 1978 May 19;200(4343):793-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/565535" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Behavior, Animal/drug effects
;
Bradykinin/pharmacology
;
Cholecystokinin/administration & dosage/*pharmacology
;
Dose-Response Relationship, Drug
;
Feeding Behavior/*drug effects
;
Humans
;
Male
;
Peptide Fragments/pharmacology
;
Rats
;
Stress, Psychological
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
Permalink
