Publication Date:
2009-04-03
Description:
The intracellular storage and utilization of lipids are critical to maintain cellular energy homeostasis. During nutrient deprivation, cellular lipids stored as triglycerides in lipid droplets are hydrolysed into fatty acids for energy. A second cellular response to starvation is the induction of autophagy, which delivers intracellular proteins and organelles sequestered in double-membrane vesicles (autophagosomes) to lysosomes for degradation and use as an energy source. Lipolysis and autophagy share similarities in regulation and function but are not known to be interrelated. Here we show a previously unknown function for autophagy in regulating intracellular lipid stores (macrolipophagy). Lipid droplets and autophagic components associated during nutrient deprivation, and inhibition of autophagy in cultured hepatocytes and mouse liver increased triglyceride storage in lipid droplets. This study identifies a critical function for autophagy in lipid metabolism that could have important implications for human diseases with lipid over-accumulation such as those that comprise the metabolic syndrome.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2676208/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2676208/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Singh, Rajat -- Kaushik, Susmita -- Wang, Yongjun -- Xiang, Youqing -- Novak, Inna -- Komatsu, Masaaki -- Tanaka, Keiji -- Cuervo, Ana Maria -- Czaja, Mark J -- K01 DK087776/DK/NIDDK NIH HHS/ -- P01 AG031782/AG/NIA NIH HHS/ -- P01 AG031782-01A1/AG/NIA NIH HHS/ -- P30 AG038072/AG/NIA NIH HHS/ -- R01 AG021904/AG/NIA NIH HHS/ -- R01 AG021904-07/AG/NIA NIH HHS/ -- R01 DK061498/DK/NIDDK NIH HHS/ -- R01 DK061498-05/DK/NIDDK NIH HHS/ -- England -- Nature. 2009 Apr 30;458(7242):1131-5. doi: 10.1038/nature07976. Epub 2009 Apr 1.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Medicine, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19339967" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Autophagy/drug effects/*physiology
;
Cell Line
;
Cholesterol/metabolism
;
Dietary Fats/pharmacology
;
Fatty Acids/*metabolism
;
Food Deprivation
;
Hepatocytes/cytology/drug effects/metabolism
;
*Lipid Metabolism/drug effects
;
Lipolysis/drug effects
;
Liver/cytology/drug effects/metabolism
;
Lysosomes/metabolism
;
Mice
;
Microtubule-Associated Proteins/deficiency/genetics
;
Oxidation-Reduction
;
Phagosomes/metabolism
;
Rats
;
Triglycerides/metabolism
Print ISSN:
0028-0836
Electronic ISSN:
1476-4687
Topics:
Biology
,
Chemistry and Pharmacology
,
Medicine
,
Natural Sciences in General
,
Physics
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