ISSN:
0170-2041
Keywords:
Fagomine
;
Enzymes
;
Transketolase
;
Carbohydrates
;
Yeast transketolase
;
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Enzyme-Catalyzed Reactions, 13. - A New, Efficient Synthesis of Fagomine2-Deoxy-L-threo-5-hexulosonitrile (4) is obtained in excellent chemical yield by yeast transketolase (EC 2.2.1.1)-catalyzed reaction of racemic 3-hydroxy-4-oxobutyronitrile [(R/S)-2] with lithium hydroxypyruvate (3). Catalytic hydrogenation of 4 exclusively gives fagomine (7).
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/jlac.1992199201201
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