ISSN:
0170-2041
Keywords:
Glucuronidation
;
Invertomers
;
Esterase
;
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Synthesis of a Metabolite of Ciamexon Conjugated with D-Glucuronic AcidReaction of the alcohol 2 with the glucuronic acid derivative 6 in the presence of Ag triflate yields the protected β-D-glucuronide 8 by rearrangement of the orthoester 7. After deacetylation and saponification with pig liver esterase, the deblocked glucuronide 3 can be isolated. Due to the aziridine ring the glucuronic acid derivatives of 2 consist of a mixture of invertomers, as shown by 1H-NMR spectroscopy.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/jlac.198919890168
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