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The biologically active conformation of ergot alkaloids (1986)

Kidrič, J. ; Kocjan, D. ; Hadži, D.

Springer

Cellular and molecular life sciences 42 (1986), S. 327-328

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ISSN: 1420-9071

Keywords: Ergot alkaloids ; bioactive conformation ; dopamine receptors ; NMR

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Medicine

Notes: Summary Molecular mechanics and NMR studies of the D ring conformation of ergot alkaloids demonstrate that both D1 and D2 forms may exist in solution. The comparison of the geometric parameters defining the spatial relations between the aromatic moieties and the basic nitrogen of conformationally restricted dopamine analogs, and that of ergolene, shows the D1 conformation to be the bioactive one.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01942524

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