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  • Epidemiology  (1)
  • Key words: Sexually transmitted disease  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Journal of mathematical biology 35 (1997), S. 629-656 
    ISSN: 1432-1416
    Keywords: Key words: Tuberculosis ; Antibiotic resistance ; Epidemiology ; Co-existence ; Dynamical systems
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Mathematics
    Notes: Abstract . Incomplete treatment of patients with infectious tuberculosis (TB) may not only lead to relapse but also to the development of antibiotic resistant TB – one of the most serious health problems facing society today. In this article, we formulate one-strain and two-strain TB models to determine possible mechanisms that may allow for the survival and spread of naturally resistant strains of TB as well as antibiotic-generated resistant strains of TB. Analysis of our models shows that non-antibiotic co-existence is possible but rare for naturally resistant strains while co-existence is almost the rule for strains that result from the lack of compliance with antibiotic treatment by TB infected individuals.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-1416
    Keywords: Key words: Sexually transmitted disease ; Pathogen strains ; Coexistence
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Mathematics
    Notes: Abstract.  We study the dynamics of sexually transmitted pathogens in a heterosexually active population, where females are divided into two different groups based on their susceptibility to two distinct pathogenic strains. It is assumed that a host cannot be invaded simultaneously by both disease agents and that when symptoms appear – a function of the pathogen, strain, virulence, and an individual’s degree of susceptibility – then individuals are treated and/or recover. Heterogeneity in susceptibility to the acquisition of infection and/or in variability in the length of the infection period of the female subpopulations is incorporated. Pathogens’ coexistence is highly unlikely on homogeneously mixing female and male populations with no heterogeneity among individuals of either gender. Variability in susceptibility in the female subpopulation makes coexistence possible albeit under a complex set of circumstances that must include differences in contact/mixing rates between the groups of females and the male population as well as differences in the lengths of their average periods of infectiousness for the three groups.
    Type of Medium: Electronic Resource
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