ISSN:
1420-9071
Keywords:
Oridonin
;
Rabdosia diterpenoid
;
thiol-reactive agent
;
misonidazole
;
radiosensitizer
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Summary The radiosensitization brought about by oridonin, one of theRabdosia diterpenoids, alone or in combination with misonidazole, was investigated in Chinese hamster V79 cells. The enhancement ratio of 1.92 was obtained when 0.01 mM oridonin and 1 mM misonidazole were administered to hypoxic cells under radiation. The enhancement ratios of oridonin and misonidazole for hypoxic cells were 1.16 and 1.59 respectively. Hence, a supra-additive effect was obtained by the combined treatment with these two drugs. Under aerobic conditions, no effect of 0.01 mM oridonin on the radiosensitization caused by misonidazole was observed.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01945533
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