ISSN:
1434-193X
Keywords:
Ene reactions
;
Azepines
;
Aminoacroleins
;
Chemistry
;
General Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
---The reaction of 3-[N-(alk-2-enyl)benzylamino]-2-cyanoacroleins 9 with primary amines 12 and 13 gave 4,5-dihydro-1H-azepines 14 and 15 stereoselectively, through an intramolecular ene reaction of the imine derivatives of 9. Similarly, carbonyl-ene reaction of acrolein derivatives 9, and olefin-ene reaction of their conjugated diene compounds 22, and 24-27 are also discussed. These ene reactions established an efficient synthetic approach toward monocyclic azepine ring formation.
Additional Material:
1 Ill.
Type of Medium:
Electronic Resource
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