Publication Date:
1997-06-13
Description:
Retinal neovascularization is the major cause of untreatable blindness. The role of growth hormone (GH) in ischemia-associated retinal neovascularization was studied in transgenic mice expressing a GH antagonist gene and in normal mice given an inhibitor of GH secretion (MK678). Retinal neovascularization was inhibited in these mice in inverse proportion to serum levels of GH and a downstream effector, insulin-like growth factor-I (IGF-I). Inhibition was reversed with exogenous IGF-I administration. GH inhibition did not diminish hypoxia-stimulated retinal vascular endothelial growth factor (VEGF) or VEGF receptor expression. These data suggest that systemic inhibition of GH or IGF-I, or both, may have therapeutic potential in preventing some forms of retinopathy.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Smith, L E -- Kopchick, J J -- Chen, W -- Knapp, J -- Kinose, F -- Daley, D -- Foley, E -- Smith, R G -- Schaeffer, J M -- EY08670/EY/NEI NIH HHS/ -- New York, N.Y. -- Science. 1997 Jun 13;276(5319):1706-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Ophthalmology, Harvard Medical School and Children's Hospital, Boston, MA 02115, USA. smith_lo@a1.tch.harvard.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9180082" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Endothelial Growth Factors/genetics/metabolism
;
Growth Hormone/agonists/antagonists & inhibitors/blood/pharmacology/*physiology
;
Hormone Antagonists/pharmacology
;
Insulin-Like Growth Factor I/metabolism/pharmacology
;
Ischemia
;
Lymphokines/genetics/metabolism
;
Mice
;
Mice, Inbred C57BL
;
Mice, Transgenic
;
Peptides, Cyclic/pharmacology
;
Recombinant Proteins/pharmacology
;
Retinal Neovascularization/*etiology/metabolism/pathology
;
Retinal Vessels
;
Vascular Endothelial Growth Factor A
;
Vascular Endothelial Growth Factors
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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