Publication Date:
1985-04-05
Description:
Soluble oligosaccharides derived from the surface of human erythrocytes were tested for their ability to competitively inhibit invasion of erythrocytes by Plasmodium falciparum, a malarial parasite. Invasion was most effectively inhibited by erythroglycan, a carbohydrate component of the band 3 transmembrane protein. The lactosamine chains of erythroglycan contributed much of the inhibitory activity. This indication of a primary parasite interaction site on band 3 supports a role for this protein in mediating the radical alterations of the erythrocyte cytoskeleton that accompany invasion.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Friedman, M J -- Fukuda, M -- Laine, R A -- New York, N.Y. -- Science. 1985 Apr 5;228(4695):75-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3883494" target="_blank"〉PubMed〈/a〉
Keywords:
Anion Exchange Protein 1, Erythrocyte/*physiology
;
Endocytosis
;
Erythrocyte Membrane/*parasitology
;
Humans
;
Malaria/physiopathology
;
Membrane Proteins/physiology
;
Plasmodium falciparum/*physiology
;
Spectrin/physiology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
Permalink
