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  • Electronic structure and strongly correlated systems  (5)
  • RNA, Untranslated/genetics/*metabolism  (2)
  • 1
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    Intersection of the RNA interference and X-inactivation pathways (2008)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2008-06-07
    Description: In mammals, dosage compensation is achieved by X-chromosome inactivation (XCI) in the female. The noncoding Xist gene initiates silencing of the X chromosome, whereas its antisense partner Tsix blocks silencing. The complementarity of Xist and Tsix RNAs has long suggested a role for RNA interference (RNAi). Here, we report that murine Xist and Tsix form duplexes in vivo. During XCI, the duplexes are processed to small RNAs (sRNAs), most likely on the active X (Xa) in a Dicer-dependent manner. Deleting Dicer compromises sRNA production and derepresses Xist. Furthermore, without Dicer, Xist RNA cannot accumulate and histone 3 lysine 27 trimethylation is blocked on the inactive X (Xi). The defects are partially rescued by truncating Tsix. Thus, XCI and RNAi intersect, down-regulating Xist on Xa and spreading silencing on Xi.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2584363/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2584363/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ogawa, Yuya -- Sun, Bryan K -- Lee, Jeannie T -- R01 GM058839/GM/NIGMS NIH HHS/ -- R01 GM058839-10/GM/NIGMS NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2008 Jun 6;320(5881):1336-41. doi: 10.1126/science.1157676.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular Biology, Massachusetts General Hospital and Howard Hughes Medical Institute, Boston, MA 02114, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18535243" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Differentiation ; Cells, Cultured ; DEAD-box RNA Helicases/genetics/metabolism ; Embryonic Stem Cells ; Endoribonucleases/genetics/metabolism ; Female ; Histones/metabolism ; Male ; Methylation ; Mice ; *RNA Interference ; RNA, Double-Stranded/metabolism ; RNA, Long Noncoding ; RNA, Small Nuclear/metabolism ; RNA, Untranslated/genetics/*metabolism ; Reverse Transcriptase Polymerase Chain Reaction ; Ribonuclease III ; X Chromosome/*genetics/metabolism ; *X Chromosome Inactivation
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Polycomb proteins targeted by a short repeat RNA to the mouse X chromosome (2008)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2008-11-01
    Description: To equalize X-chromosome dosages between the sexes, the female mammal inactivates one of her two X chromosomes. X-chromosome inactivation (XCI) is initiated by expression of Xist, a 17-kb noncoding RNA (ncRNA) that accumulates on the X in cis. Because interacting factors have not been isolated, the mechanism by which Xist induces silencing remains unknown. We discovered a 1.6-kilobase ncRNA (RepA) within Xist and identified the Polycomb complex, PRC2, as its direct target. PRC2 is initially recruited to the X by RepA RNA, with Ezh2 serving as the RNA binding subunit. The antisense Tsix RNA inhibits this interaction. RepA depletion abolishes full-length Xist induction and trimethylation on lysine 27 of histone H3 of the X. Likewise, PRC2 deficiency compromises Xist up-regulation. Therefore, RepA, together with PRC2, is required for the initiation and spread of XCI. We conclude that a ncRNA cofactor recruits Polycomb complexes to their target locus.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2748911/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2748911/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zhao, Jing -- Sun, Bryan K -- Erwin, Jennifer A -- Song, Ji-Joon -- Lee, Jeannie T -- R01 GM058839/GM/NIGMS NIH HHS/ -- R01 GM058839-10/GM/NIGMS NIH HHS/ -- R01 GM110090/GM/NIGMS NIH HHS/ -- R01GM58839/GM/NIGMS NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2008 Oct 31;322(5902):750-6. doi: 10.1126/science.1163045.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute, Boston, MA 02115, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18974356" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Differentiation ; Cell Line ; Chromatin Immunoprecipitation ; Electrophoretic Mobility Shift Assay ; Embryonic Stem Cells ; Female ; Fibroblasts ; Male ; Mice ; Mice, Transgenic ; Molecular Sequence Data ; Polycomb-Group Proteins ; Polymerase Chain Reaction ; RNA, Long Noncoding ; RNA, Untranslated/genetics/*metabolism ; Repetitive Sequences, Nucleic Acid ; Repressor Proteins/*metabolism ; Up-Regulation ; X Chromosome/*metabolism ; X Chromosome Inactivation
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Reduction of the low-temperature bulk gap in samarium hexaboride under high magnetic fields (2017)
    American Physical Society (APS)
    Details
    Publication Date: 2017-06-14
    Description: Author(s): S. Wolgast, Y. S. Eo, K. Sun, Ç. Kurdak, F. F. Balakirev, M. Jaime, D.-J. Kim, and Z. Fisk SmB 6 exhibits a small (15–20 meV) band gap at low temperatures due to hybridized d and f electrons, a tiny (3 meV) transport activation energy E A above 4 K, and surface states accessible to transport below 2 K. We study its magnetoresistance in 60-T pulsed fields between 1.5 and 4 K. The response of… [Phys. Rev. B 95, 245112] Published Tue Jun 13, 2017
    Keywords: Electronic structure and strongly correlated systems
    Print ISSN: 1098-0121
    Electronic ISSN: 1095-3795
    Topics: Physics
    Published by American Physical Society (APS)
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  • 4
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    Anomalous nanoclusters, anisotropy, and electronic nematicity in the doped manganite La_{1/3} Ca_{2/3} MnO_{3} (2017)
    American Physical Society (APS)
    Details
    Publication Date: 2017-06-08
    Description: Author(s): J. Tao, K. Sun, J. M. Tranquada, and Y. Zhu In doped manganites, a superlattice (SL) modulation associated with charge/orbital ordering is accepted as a key component in understanding many intriguing properties. It has been reported that the SL modulation always appears on the a axis of the crystals. Here, by using multiple transmission elect… [Phys. Rev. B 95, 235113] Published Wed Jun 07, 2017
    Keywords: Electronic structure and strongly correlated systems
    Print ISSN: 1098-0121
    Electronic ISSN: 1095-3795
    Topics: Physics
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  • 5
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    Understanding low-temperature bulk transport in samarium hexaboride without relying on in-gap bulk states (2017)
    American Physical Society (APS)
    Details
    Publication Date: 2017-05-18
    Description: Author(s): A. Rakoski, Y. S. Eo, K. Sun, and Ç. Kurdak We present a new model to explain the difference between the transport and spectroscopy gaps in samarium hexaboride ( SmB 6 ), which has been a mystery for some time. We propose that SmB 6 can be modeled as an intrinsic semiconductor with an accumulation length that diverges at cryogenic temperatures. I… [Phys. Rev. B 95, 195133] Published Wed May 17, 2017
    Keywords: Electronic structure and strongly correlated systems
    Print ISSN: 1098-0121
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    Topics: Physics
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  • 6
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    Neutron, electron, and x-ray scattering investigation of Cr1−xVx near quantum criticality (2014)
    American Physical Society (APS)
    Details
    Publication Date: 2014-07-30
    Description: Author(s): D. A. Sokolov, M. C. Aronson, L. Wu, Y. Zhu, C. Nelson, J. F. Mansfield, K. Sun, R. Erwin, J. W. Lynn, M. Lumsden, and S. E. Nagler The weakness of electron-electron correlations in the itinerant antiferromagnet Cr doped with V has long been considered the reason that neither new collective electronic states nor even non-Fermi-liquid behavior are observed when antiferromagnetism in Cr1−xVx is suppressed to zero temperature. We p... [Phys. Rev. B 90, 035139] Published Tue Jul 29, 2014
    Keywords: Electronic structure and strongly correlated systems
    Print ISSN: 1098-0121
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    Topics: Physics
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  • 7
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    Magnetotransport measurements of the surface states of samarium hexaboride using Corbino structures (2015)
    American Physical Society (APS)
    Details
    Publication Date: 2015-09-05
    Description: Author(s): S. Wolgast, Y. S. Eo, T. Öztürk, G. Li, Z. Xiang, C. Tinsman, T. Asaba, B. Lawson, F. Yu, J. W. Allen, K. Sun, L. Li, Ç. Kurdak, D.-J. Kim, and Z. Fisk The recent conjecture of a topologically protected surface state in SmB 6 and the verification of robust surface conduction below 4 K have prompted a large effort to understand surface states. Conventional Hall transport measurements allow current to flow on all surfaces of a topological insulator, s… [Phys. Rev. B 92, 115110] Published Fri Sep 04, 2015
    Keywords: Electronic structure and strongly correlated systems
    Print ISSN: 1098-0121
    Electronic ISSN: 1095-3795
    Topics: Physics
    Published by American Physical Society (APS)
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