ISSN:
1573-3904
Keywords:
Antifungal
;
Cytotoxic
;
Synergism
;
Marfey's reagent
;
E-didehydroaminobutyric acid
;
β-Aminodeca(octa)noic acids
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract The tropical marine cyanobacterium Lyngbyamajuscula produces a series of cytotoxic andantimicrobial cyclic peptides. The totalstructure of the two major components,laxaphycins A and B, was determined byinterpretation of physical data, principallyhigh field NMR, FAB MS and MS/MS, in combinationwith chemical derivatization and degradationschemes. Absolute stereochemistries of thenatural and ‘exotic’ amino acids weredetermined. The two cyclic peptides exhibited anunusual biological synergism when tested forantifungal or cytotoxic effects.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1008884402484
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