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  • 1
    Electronic Resource
    Electronic Resource
    The genetics of position — effect variegation modifying loci inDrosophila melanogaster (1989)
    Springer
    Molecular genetics and genomics 217 (1989), S. 520-527 
    Details
    ISSN: 1617-4623
    Keywords: Drosophila melanogaster ; Position-effect variegation ; Modifier loci ; Gene dosage effects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary The dose dependent effects of position-effect variegation (PEV) modifying genes were studied in chromosome arms2L, 2R and3R. Four groups of PEV modifying genes can be distinguished: haplo-abnormal suppressor and enhancer loci with or without a triplo-effect. using duplications four triplo-abnormal suppressor and four triplo-abnormal enhancer functions were localized. In two cases we proved that these functions correspond to a converse haplo-abnormal one. Altogether 43 modifier loci were identified. Most of these loci proved not to display significant triplo-effects (35). The group of haplo-abnormal loci with a triplo-effect may represent genes which play an important role in heterochromatin packaging.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02464926
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  • 2
    Electronic Resource
    Electronic Resource
    Modifiers of position-effect variegation in the region from 86C to 88B of the Drosophila melanogaster third chromosome (1987)
    Springer
    Molecular genetics and genomics 210 (1987), S. 429-436 
    Details
    ISSN: 1617-4623
    Keywords: Drosophila melanogaster ; Position-effect variegation ; Cytogenetic mapping
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Four dominant suppressor and one enhancer of variegation loci were mapped in the polytene chromosome region extending from section 86C to section 88B of the Drosophila melanogaster third chromosome using a set of deficiencies. The suppressor locus Su-var(3) 14 maps in 86CD, Su-var(3) 13 in 86F4-7, Su-var(3)6 in 87B4-7 and Su-var(3)7 in 87E4-5. The enhancer locus E-var(3)3 maps in 87E12-F11. Su-var(3)13, Su-var(3)6 and Su-var(3)7 are also defined by point mutant alleles originally identified by other criteria (Reuter et al. 1986). Duplications covering the suppressor loci Su-var(3)14, Su-var(3)13, Su-var(3)6 and Su-var(3)7 were found to reduce considerably the haplo-abnormal effect of heterozygous point mutants of the corresponding loci. One suppressor locus, Su-var(3)7, maps within a region which has previously been cloned. The positions of deficiency breakpoints delimiting the suppressor locus indicate that all the necessary sequences for its function are located within 10 kb of cloned DNA.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00327193
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  • 3
    Electronic Resource
    Electronic Resource
    Third chromosome suppressor of position-effect variegation loci in Drosophila melanogaster (1986)
    Springer
    Molecular genetics and genomics 202 (1986), S. 481-487 
    Details
    ISSN: 1617-4623
    Keywords: Position-effect variegation ; Suppressor mutations ; Chromosome 3 ; Heterochromatin ; Drosophila melanogaster
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary As a result of a genetic analysis of 63 third chromosome suppressor mutations of position-effect variegation 12 different loci showing dominant suppression have been identified and their map positions determined. A compilcation of the genetic data available for each suppressor locus is given. The strong suppressor effects of the mutations have been quantified by measurements of white variegation inw m4h /w m4h ,w m4h /Y andw m4h /O flies. Mutant alleles of three loci were found in these studies to dominate over the strong enhancer effect of complete loss of the Y chromosome. Most of the identified loci suppressing position-effect variegation represent essential genetic funtions; only three loci represent nonessential functions. Mutations of two loci display recessive butyrate sensitivity and lethal interaction with the heterochromatic Y chromosome suggesting that these genes affect chromosomal condensation. Studies with deficiencies and triploids revealed that most of the loci represent haplo-abnormal suppressor functions. The use of the isolated mutant material for genetic, developmental and molecular studies of processes connected with gene inactivation in position-effect variegation is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00333281
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