Publication Date:
2009-08-22
Description:
The paradigmatic feature of long-term memory (LTM) is its persistence. However, little is known about the mechanisms that make some LTMs last longer than others. In rats, a long-lasting fear LTM vanished rapidly when the D1 dopamine receptor antagonist SCH23390 was injected into the dorsal hippocampus 12 hours, but not immediately or 9 hours, after the fearful experience. Conversely, intrahippocampal application of the D1 agonist SK38393 at the same critical post-training time converted a rapidly decaying fear LTM into a persistent one. This effect was mediated by brain-derived neurotrophic factor and regulated by the ventral tegmental area (VTA). Thus, the persistence of LTM depends on activation of VTA/hippocampus dopaminergic connections and can be specifically modulated by manipulating this system at definite post-learning time points.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rossato, Janine I -- Bevilaqua, Lia R M -- Izquierdo, Ivan -- Medina, Jorge H -- Cammarota, Martin -- New York, N.Y. -- Science. 2009 Aug 21;325(5943):1017-20. doi: 10.1126/science.1172545.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Centro de Memoria, Instituto do Cerebro, Pontificia Universidade Catolica do Rio Grande do Sul, Porto Alegre, Brazil.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19696353" target="_blank"〉PubMed〈/a〉
Keywords:
2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine/pharmacology
;
8-Bromo Cyclic Adenosine Monophosphate/pharmacology
;
Animals
;
Benzazepines/pharmacology
;
Brain-Derived Neurotrophic Factor/metabolism
;
Dopamine/*physiology
;
Dopamine Agonists/pharmacology
;
Dopamine Antagonists/pharmacology
;
Fear
;
Hippocampus/drug effects/*physiology
;
Male
;
Memory/drug effects/*physiology
;
Phosphorylation
;
Rats
;
Rats, Wistar
;
Receptors, Dopamine D1/agonists/antagonists & inhibitors/metabolism
;
Receptors, N-Methyl-D-Aspartate/metabolism
;
Time Factors
;
Tyrosine 3-Monooxygenase
;
Ventral Tegmental Area/*physiology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
Permalink
