ISSN:
1573-3904
Keywords:
Disulfide bond
;
DMSO oxidation
;
Oxytocin
;
Peptide synthesis
;
TFA cleavage
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Summary Oxytocin, a nonapeptide amide, was synthesized on a PEGA-resin using the Fmoc-tBu strategy. The sulfhydryl groups of the two cysteine residues were protected with trityl groups. Different oxidation reagents such as DMSO, I2 and thallium (III) trifluoroacetate mixed with TFA were evaluated in order to obtain oxytocin in a one-pot reaction. The mixture of TFA and DMSO (5:1) in which oxytocin was formed quantitatively was found to be the optimal method. The cyclic oxytocin could be isolated in 56% yield.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00127963
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