ISSN:
1612-1112
Keywords:
Gas-liquid chromatography
;
Reversed-phase HPLC
;
Inclusion processes
;
Cyclodextrins
;
Dimethylnaphthalenes
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Summary Reversed-phase high performance liquid chromatography and gas-liquid chromatography have been applied to studies on the complexation of cyclodextrins with isomeric dimethylnaphthalenes. Both β and γ-cyclodextrins have been found to form inclusion complexes with dimethylnaphthalenes. With the exception of the complex of 1,8-dimethylnaphthalene with β-cyclodextrin, all the other complexes under investigation are of moderate stability. The remarkable affinity of β-cyclodextrin for 1,8-dimethylnaphthalene has been observed by both GC and HPLC. The stability constant of this complex was always about 1.5–2.0 orders of magnitude greater than the corresponding value for the other isomers. The chromatographic data suggest that there is an especially good fit of the 1,8-dimethylnaphthalene molecule into the β-cyclodextrin cavity. The importance of studying the complicated phenomena of complexation by cyclodextrin using various experimental and theoretical methods is stressed.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02267929
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