ISSN:
1573-6822
Keywords:
arborescent cytoplasmic processes
;
DNA synthesis
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract TGF-β1 is known as a potent inhibitor of proliferation of rat and human hepatocytes. In this study we show that the effects of TGF-β1 are quite different on mouse hepatocytes. In rat and human hepatocytes, TGF-β1 inhibited DNA synthesis and also inhibited the morphological changes induced by growth factors in rat and human hepatocytes. In contrast, addition of TGF-β1 to mouse hepatocytes resulted in pronounced alterations in morphology of these cells. These changes were similar to those induced by HGF and EGF. The induction of structural changes by TGF-β1 was noted only in mouse hepatocytes. Mouse hepatocytes were also much more resistant to the mito-inhibitory effect of TGF-β1. These findings suggest profound differences in hepatocyte growth regulation between these species and may relate to observed differences in susceptibility to carcinogenesis.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00756762
Permalink
