ISSN:
1617-4623
Keywords:
DNA repair
;
Recombination
;
Virulence
;
Mutation
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
Notes:
Abstract The recA + gene of Vibrio cholerae O1 has been cloned, its nucleotide sequence determined and the product characterized. A deletion mutation was constructed in the recA gene and mutants showed the typical sensitivity to UV and to DNA-damaging agents, as well as an inability to mediate homologous DNA recombination. The chromosomal recA deletion mutants in V. cholerae do not show altered virulence in the infant mouse cholera model and are thus ideal strains for use in complementation studies.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00285457
Permalink