ISSN:
1573-4927
Keywords:
alcohol dehydrogenase
;
null allele
;
DNA rearrangement
;
Drosophila melanogaster
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Chemistry and Pharmacology
Notes:
Abstract An alcohol dehydrogenase null activity allele,Adh nAH52 , extracted from a natural population ofDrosophila melanogaster has been cloned and sequenced. Compared with the wild-type consensus sequence, the nucleotide sequence ofAdh nAH52 contains eight extra bases in intron 2, adjacent to the 5' splice site. It seems likely that the extra bases result from two structural changes, with a 10-base pair insertion at the same site as a 2-base pair deletion. The insertion includes an 8-base pair duplication of an adjoining region. This structural change alters transcription to give rise to an mRNA which is longer than normal and at 10% of the wild-type level.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00553989
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