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  • DNA instability  (1)
  • Earth Resources and Remote Sensing  (1)
  • 1
    Publication Date: 2019-05-21
    Description: The Advanced Very High Resolution Radiometer (AVHRR) sensor provides a unique global remote sensing dataset that ranges from the 1980's to the present. Over the years, several efforts have been made on the calibration of the different instruments to establish a consistent land surface reflectance time-series and to augment the AVHRR data record with data from other sensors such as the Moderate Resolution Imaging Spectroradiometer (MODIS). In this paper, we present a summary of all the corrections applied to the AVHRR Surface Reflectance and NDVI Version 4 Product, developed in the framework of the National Oceanic and Atmospheric Administration (NOAA) Climate Data Record (CDR) program. These corrections result from assessment of the geo-location, improvement of the cloud masking and calibration monitoring. Additionally, we evaluate the performance of the surface reflectance over the AERONET sites by a cross-comparison with MODIS, which is an already validated product, and evaluation of a downstream Leaf Area Index (LAI) product. We demonstrate the utility of this long time-series by estimating the winter wheat yield over the USA. The methods developed by [1] and [2] are applied to both the MODIS and AVHRR data. Comparison of the results from both sensors during the MODIS-era shows the consistency of the dataset with similar errors of 10%. When applying the methods to AVHRR historical data from the 1980's, the results have errors equivalent to those derived from MODIS.
    Keywords: Earth Resources and Remote Sensing
    Type: GSFC-E-DAA-TN40735 , Remote Sensing (e-ISSN 2072-4292); 9; 3; 296
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  • 2
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-05
    Description: It has been more than 25 years since the identification of the FMR1 gene and the demonstration of the causative role of CGG-repeat expansion in the disease pathology of fragile X syndrome (FXS), but the underlying mechanisms involved in the expansion mutation and the resulting gene silencing still remain elusive. Our understanding of the pathways impacted by the loss of FMRP function has grown tremendously, and has opened new avenues for targeted treatments for FXS. However, the failure of recent clinical trials that were based on successful preclinical studies using the Fmr1 knockout mouse model has forced the scientific community to revisit clinical trial design and identify objective outcome measures. There has also been a renewed interest in restoring FMR1 gene expression as a possible treatment approach for FXS. This special issue of Brain Sciences highlights the progress that has been made towards understanding the disease mechanisms and how this has informed the development of treatment strategies that are being explored for FXS.
    Keywords: QH301-705.5 ; Q1-390 ; n/a ; lymphoblast ; pluripotent stem cells ; FMR1 ; Gene editing ; X chromosome ; Fmr1 ; epigenetic gene silencing ; FMR1 gene ; Fragile X syndrome 1 ; repeat instability ; characteristics that have the greatest impact ; DNA instability ; working memory ; language development ; mosaicism ; CRISPR 3 ; clinical trials ; autism spectrum disorders ; Fmr1 KO mouse ; automated vocal analysis ; base excision repair (BER) ; inhibitory control ; cerebral spinal fluid ; iPSC ; drug development ; targeted treatments ; molecular biomarkers ; viral vector ; avoidance ; biomarker ; set-shifting ; early identification ; expansion ; anxiety ; planning ; voice of the person ; mismatch repair (MMR) ; gene reactivation ; double-strand break repair (DSBR) ; newborn screening ; intellectual disability ; processing speed ; voice of the patient ; fragile X syndrome ; adeno-associated virus ; neurodevelopmental disorders ; histone methylation ; Non-homologous end-joining (NHEJ) ; ASD ; Fxr2 ; Fragile X-associated Tremor/Ataxia Syndrome 2 ; Trinucleotide Repeat 4 ; CGG Repeat Expansion Disease ; DNA methylation ; contraction ; fragile X mental retardation protein ; RNA:DNA hybrid ; behavior ; developmental disorders ; cognition ; females ; FMRP ; Fragile X Syndrome ; unstable repeat diseases ; protein synthesis ; brain ; cognitive flexibility ; treatment development ; fibroblast ; PRC2 ; transcription coupled repair (TCR) ; best practices ; attention ; Fragile X ; executive function ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences
    Language: English
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