ISSN:
1612-1112
Keywords:
Column dead-time
;
Supercritical-fluid chromatography
;
Cyclodextrin stationary phase
;
van der Waals' surface area
;
van der Waals' retention factor
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Summary An analytical relationship between retention time and the van der Waals' surface area of solute molecules has been investigated for the members of a homologous series. In the case of two homologous series, n-alkanes and alkylbenzenes, the validity of this relationship was experimentally verified on a supercritical-fluid chromatographic column packed with β-cyclodextrin. A new chromatographic parameter, the van der Waals' retention factor, is also defined. The solute retention time in the investigated systems was found to be a linear function of the van der Waals' retention factor. The relationship led to a new definition of the column dead-time, and was found to be the retention time of a hypothetical solute with “zero” van der Waals' surface area. Using this linear relationship the column dead-time can be determined. The retention data of the two homologous series obtained under identical experimental conditions gave very similar values for the column dead-time.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02262387
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