Publication Date:
2003-08-09
Description:
The amygdalohippocampal circuit plays a pivotal role in Pavlovian fear memory. We simultaneously recorded electrical activity in the lateral amygdala (LA) and the CA1 area of the hippocampus in freely behaving fear-conditioned mice. Patterns of activity were related to fear behavior evoked by conditioned and indifferent sensory stimuli and contexts. Rhythmically synchronized activity at theta frequencies increased between the LA and the CA1 after fear conditioning and became significant during confrontation with conditioned fear stimuli and expression of freezing behavior. Synchronization of theta activities in the amygdalohippocampal network represents a neuronal correlate of conditioned fear, apt to improve neuronal communication during memory retrieval.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Seidenbecher, Thomas -- Laxmi, T Rao -- Stork, Oliver -- Pape, Hans-Christian -- New York, N.Y. -- Science. 2003 Aug 8;301(5634):846-50.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institut fur Physiologie, Otto-von-Guericke-Universitat, Leipziger Strasse 44, Magdeburg D-39120, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12907806" target="_blank"〉PubMed〈/a〉
Keywords:
Amygdala/*physiology
;
Animals
;
Behavior, Animal
;
Conditioning (Psychology)
;
Cues
;
Electrophysiology
;
Electroshock
;
*Fear
;
Hippocampus/*physiology
;
Male
;
*Memory
;
Mice
;
Mice, Inbred C57BL
;
Motor Activity
;
*Theta Rhythm
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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