ISSN:
0935-6304
Keywords:
High performance thin-layer chromatography
;
β-adrenoceptor blocking drugs
;
Continuous development
;
Multiple development
;
Chemistry
;
Analytical Chemistry and Spectroscopy
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
High performance thin-layer chromatography was used for the separation of nine therapeutically important and structurally similar β-adrenoceptor blocking drugs on silica gel plates. In situ scanning of the plate in the reflectance mode gave detection limits in the low nanogram range depending on the individual drug and the wavelength selected for its determination. Scanning the HPTLC plate at several wavelengths can be used to aid the identification of partially resolved components. Continuous development and continuous multiple development techniques are compared for the simultaneous separation of the drug mixture.
Additional Material:
7 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/jhrc.1240030905
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