ISSN:
0749-1581
Keywords:
Proton selective relaxation
;
Conformational analysis
;
Molecular motion and dynamics
;
13C NMR spin-lattice relaxation
;
Chemistry
;
Analytical Chemistry and Spectroscopy
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The conformational and dynamic properties of inosine and two other components of inosiplex (p-acetamidobenzoic acid and dimethylaminoisopropanol) were analysed. For inosine, the most interesting molecule of the complex, the rotamer populations of all six allowed structures related to the N ⇌ S puckering and the 5′-exocyclic conformation were calculated. Analysis of different NMR spectra and/or parameters, i.e. 2D-NOE, saturation transfer, spinlattice relaxation rates and scalar coupling constants, suggests that a distribution of several inosine structures occurs in solution, with the inosine syn conformation predominating.
Additional Material:
5 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/mrc.1260280413
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