Publication Date:
1993-07-09
Description:
Immunoconjugates (BR96-DOX) were prepared between chimeric monoclonal antibody BR96 and the anticancer drug doxorubicin. The monoclonal antibody binds an antigen related to Lewis Y that is abundantly expressed at the surface of cells from many human carcinomas; it has a high degree of tumor selectivity and is internalized after binding. BR96-DOX induced complete regressions and cures of xenografted human lung, breast, and colon carcinomas growing subcutaneously in athymic mice and cured 70 percent of mice bearing extensive metastases of a human lung carcinoma. Also, BR96-DOX cured 94 percent of athymic rats with subcutaneous human lung carcinoma, even though the rats, like humans and in contrast to mice, expressed the BR96 target antigen in normal tissues.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Trail, P A -- Willner, D -- Lasch, S J -- Henderson, A J -- Hofstead, S -- Casazza, A M -- Firestone, R A -- Hellstrom, I -- Hellstrom, K E -- New York, N.Y. -- Science. 1993 Jul 9;261(5118):212-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, NJ 08543.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8327892" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Antibodies, Monoclonal/administration & dosage/immunology/*therapeutic use
;
Antigens, Neoplasm/immunology
;
Antigens, Surface/immunology
;
Breast Neoplasms/drug therapy
;
Colonic Neoplasms/drug therapy
;
Doxorubicin/administration & dosage/*therapeutic use
;
Humans
;
Immunotoxins/administration & dosage/*therapeutic use
;
Lung Neoplasms/drug therapy
;
Mice
;
Mice, Nude
;
Neoplasm Transplantation
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Neoplasms, Experimental/*drug therapy
;
Rats
;
Rats, Nude
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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