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Possible geothermal resources in the Coast Plutonic Complex of southern British Columbia, Canada (1978)

Lewis, T. J. ; Judge, A. S. ; Souther, J. G.

Springer

Pure and applied geophysics 117 (1978), S. 172-179

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ISSN: 1420-9136

Keywords: Coast Plutonic Complex ; Quaternary volcanism ; Plate tectonics ; Heat flow ; Heat production

Source: Springer Online Journal Archives 1860-2000

Topics: Geosciences , Physics

Notes: Abstract In southern British Columbia the terrestrial heat flow is low (44 mW m−2) to the west of the Coast Plutonic Complex (CPC), average in CPC (50–60 mW m−2),and high to the east(80–90 mW m−2). The average heat flow in CPC and the low heat generation (less than 1 μW m−3) indicate that a relatively large amount of heat flows upwards into the crust which is generally quite cool. Until two million years ago the Explorer plate underthrust this part of the American plate, carrying crustal material into the mantle. Melted crustal rocks have produced the inland Pemberton and Garibaldi volcanic belts in the CPC. Meager Mountain, a volcanic complex in the CPC 150 km north of Vancouver, is a possible geothermal energy resource. It is the product of intermittent activity over a period of 4 My, the most recent eruption being the Bridge River Ash 2440 y B.P. The original explosive eruption produced extensive fracturing in the granitic basement, and a basal explosion breccia from the surface of a cold brittle crust. This breccia may be a geothermal reservoir. Other volcanic complexes in the CPC have a similar potential for geothermal energy.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00879744

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The stimulation of paracrine and autocrine mitogenic pathways by the platelet-derived growth factor receptor (1987)

Williams, Lewis T. ; Escobedo, Jaime A. ; Keating, Mark T. ; [et al.]

New York, NY [u.a.] : Wiley-Blackwell

Journal of Cellular Physiology 133 (1987), S. 27-30

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ISSN: 0021-9541

Keywords: Life and Medical Sciences ; Cell & Developmental Biology

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Biology , Medicine

Notes: Platelet-derived growth factor (PDGF) and PDGF-like polypeptides stimulate cell proliferation through paracrine and autocrine pathways. Each of these pathways is mediated by the PDGF receptor. Recently, cDNA clones for the receptor have been isolated and sequenced. The receptor gene on chromosome 5 is transcribed into a single 5.2 kb mRNA. The translated product, which is processed through at least one identifiable precursor, is expressed at the cell surface and is rapidly degraded. When activated by PDGF, the receptor mediates a group of diverse intracellular reactions. The receptor domains that mediate tyrosine kinase activity can be identified in the amino acid sequence of the receptor. However, the domains that mediate other PDGF-stimulated responses, such as turnover of phosphatidylinositol and enhanced expression of the c-myc and c-fos genes, have not been determined. Recently, a full-length receptor cDNA clone has been expressed in cells that normally lack PDGF receptors. This expression system should provide an approach to studies of the function of specific receptor domains and should help determine the relationship among the intracellular reactions stimulated by PDGF.

Additional Material: 1 Ill.