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    Genomic sequencing of Pleistocene cave bears (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-06-04
    Description: Despite the greater information content of genomic DNA, ancient DNA studies have largely been limited to the amplification of mitochondrial sequences. Here we describe metagenomic libraries constructed with unamplified DNA extracted from skeletal remains of two 40,000-year-old extinct cave bears. Analysis of approximately 1 megabase of sequence from each library showed that despite significant microbial contamination, 5.8 and 1.1% of clones contained cave bear inserts, yielding 26,861 base pairs of cave bear genome sequence. Comparison of cave bear and modern bear sequences revealed the evolutionary relationship of these lineages. The metagenomic approach used here establishes the feasibility of ancient DNA genome sequencing programs.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Noonan, James P -- Hofreiter, Michael -- Smith, Doug -- Priest, James R -- Rohland, Nadin -- Rabeder, Gernot -- Krause, Johannes -- Detter, J Chris -- Paabo, Svante -- Rubin, Edward M -- T32 HL07279/HL/NHLBI NIH HHS/ -- U1 HL66681B/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 2005 Jul 22;309(5734):597-9. Epub 2005 Jun 2.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉United States Department of Energy Joint Genome Institute, Walnut Creek, CA 94598, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15933159" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cloning, Molecular ; Computational Biology ; DNA/genetics/history ; Dogs/genetics ; *Genome ; Genomic Library ; History, Ancient ; Molecular Sequence Data ; Phylogeny ; Sequence Alignment ; *Sequence Analysis, DNA ; Ursidae/*genetics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Reverse methanogenesis: testing the hypothesis with environmental genomics (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-09-09
    Description: Microbial methane consumption in anoxic sediments significantly impacts the global environment by reducing the flux of greenhouse gases from ocean to atmosphere. Despite its significance, the biological mechanisms controlling anaerobic methane oxidation are not well characterized. One current model suggests that relatives of methane-producing Archaea developed the capacity to reverse methanogenesis and thereby to consume methane to produce cellular carbon and energy. We report here a test of the "reverse-methanogenesis" hypothesis by genomic analyses of methane-oxidizing Archaea from deep-sea sediments. Our results show that nearly all genes typically associated with methane production are present in one specific group of archaeal methanotrophs. These genome-based observations support previous hypotheses and provide an informed foundation for metabolic modeling of anaerobic methane oxidation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hallam, Steven J -- Putnam, Nik -- Preston, Christina M -- Detter, John C -- Rokhsar, Daniel -- Richardson, Paul M -- DeLong, Edward F -- New York, N.Y. -- Science. 2004 Sep 3;305(5689):1457-62.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Monterey Bay Aquarium Research Institute, Moss Landing, CA 95064, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15353801" target="_blank"〉PubMed〈/a〉
    Keywords: Anaerobiosis ; Archaea/classification/genetics/*metabolism ; Carbon Dioxide/metabolism ; Cloning, Molecular ; Gene Library ; Genes, Archaeal ; Genes, rRNA ; *Genome, Archaeal ; Geologic Sediments/*microbiology ; Methane/*metabolism ; Molecular Sequence Data ; Oxidation-Reduction ; Oxidoreductases/genetics/metabolism ; Phylogeny ; Pterins/metabolism ; RNA, Archaeal/genetics ; RNA, Ribosomal/genetics ; Seawater/microbiology ; Sulfates/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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