ISSN:
1573-739X
Keywords:
Clinical trials
;
Creams
;
Dithranol
;
Drug evaluation
;
Drug release
;
Irritation tests
;
Penetration
;
Psoriasis
;
Side effects
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract In anin vitro model, the release and penetration through a silicon membrane of different cream formulations and ointments containing 0.5% dithranol were studied. The results indicated that the method is not suitable for predictingin vivo release and penetration. Experiments with rabbits showed that the degree of skin irritation produced by a hospital-prepared product containing 0.5% dithranol was comparable to that of a commercial product. Clinical efficacy and side-effects of these two products were investigated in a double-blind left-right comparative study in 35 patients with chronic plaque psoriasis. The two creams proved to be equally effective and showed the same incidence of side-effects.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01988877
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