ISSN:
1573-3904
Keywords:
α-Benzyl-o-aminomethylphenylacetic acid
;
Cis-peptide bond mimetic
;
Cyclic somatostatin analogues
;
2D NMR conformational analysis
;
Receptor binding
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Summary A new cis-peptide bond mimetic, α-benzyl-o-aminomethylphenylacetic acid, was synthesized and incorporated in a homodetic somatostatin analogue. Biological binding tests and 2D NMR conformational analysis indicate that the configuration of the bridge-unit asymmetric center and the orientation of the benzyl side chain play a key role in the biological activity of this type of somatostatin analogues.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00119144
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