Publication Date:
2013-03-23
Description:
The air-filled cavity and ossicles of the mammalian middle ear conduct sound to the cochlea. Using transgenic mice, we show that the mammalian middle ear develops through cavitation of a neural crest mass. These cells, which previously underwent an epithelial-to-mesenchymal transformation upon leaving the neural tube, undergo a mesenchymal-to-epithelial transformation to form a lining continuous with the endodermally derived auditory tube. The epithelium derived from endodermal cells, which surrounds the auditory tube and eardrum, develops cilia, whereas the neural crest-derived epithelium does not. Thus, the cilia critical to clearing pathogenic infections from the middle ear are distributed according to developmental derivations. A different process of cavitation appears evident in birds and reptiles, indicating that this dual epithelium may be unique to mammals.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Thompson, Hannah -- Tucker, Abigail S -- G1001232/Medical Research Council/United Kingdom -- New York, N.Y. -- Science. 2013 Mar 22;339(6126):1453-6. doi: 10.1126/science.1232862.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Craniofacial Development and Stem Cell Biology, King's College London, Guy's Hospital, London, UK, SE1 9RT.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23520114" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Chick Embryo
;
Cilia/ultrastructure
;
Ear, Middle/anatomy & histology/*cytology/*embryology
;
Embryonic Development
;
Endoderm/*cytology/embryology
;
Epithelial Cells/ultrastructure
;
Epithelial-Mesenchymal Transition
;
Epithelium/*embryology/ultrastructure
;
Female
;
Lizards/anatomy & histology/embryology
;
Male
;
Mammals/anatomy & histology/embryology
;
Mesoderm/embryology
;
Mice
;
Mice, Transgenic
;
Neural Crest/*cytology/embryology
;
Shrews/anatomy & histology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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