Publication Date:
2008-07-25
Description:
Inadequate physical activity is linked to many chronic diseases. But the mechanisms that tie muscle activity to health are unclear. The transcriptional coactivator PGC1alpha has recently been shown to regulate several exercise-associated aspects of muscle function. We propose that this protein controls muscle plasticity, suppresses a broad inflammatory response and mediates the beneficial effects of exercise.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2587487/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2587487/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Handschin, Christoph -- Spiegelman, Bruce M -- R01 DK054477/DK/NIDDK NIH HHS/ -- R01 DK054477-09A1/DK/NIDDK NIH HHS/ -- England -- Nature. 2008 Jul 24;454(7203):463-9. doi: 10.1038/nature07206.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute of Physiology and Zurich Center for Integrative Human Physiology (ZIHP), University of Zurich, CH-8057 Zurich, Switzerland. christoph.handschin@access.uzh.ch〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18650917" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Chronic Disease
;
Exercise/*physiology
;
Humans
;
Inflammation/genetics/*metabolism
;
Muscle, Skeletal/metabolism/physiology
;
Obesity/genetics/immunology/physiopathology
;
Transcription Factors/genetics/*metabolism
Print ISSN:
0028-0836
Electronic ISSN:
1476-4687
Topics:
Biology
,
Chemistry and Pharmacology
,
Medicine
,
Natural Sciences in General
,
Physics
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