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Receptors for multiplication-stimulating activity (MSA) on rabbit chondrocytes (1984)

Ashton, I. K. ; Soul, J. H.

Springer

Calcified tissue international 36 (1984), S. 576-579

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ISSN: 1432-0827

Keywords: Insulinlike growth factors ; Multiplication-stimulating activity ; Chondrocytes ; Cartilage

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Medicine , Physics

Notes: Summary Multiplication-stimulating activity (125I-MSA) has been shown to bind to isolated rabbit chondrocytes, the binding being dependent on time, temperature, and cell density. Nonspecific binding was approximately 15%. Unlabelled MSA at 100 ng/ml inhibited125I-MSA binding by 50%. Porcine insulin (0.5–10 µg/ml) did not compete with MSA but resulted in a 10–15% increase in125I-MSA binding. The data suggest that normal chondrocytes carry IGF2-type receptors as well as the IGF1 type previously described.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF02405369

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