Publication Date:
2003-11-08
Description:
Here, we report evidence for the production of ozone in human disease. Signature products unique to cholesterol ozonolysis are present within atherosclerotic tissue at the time of carotid endarterectomy, suggesting that ozone production occurred during lesion development. Furthermore, advanced atherosclerotic plaques generate ozone when the leukocytes within the diseased arteries are activated in vitro. The steroids produced by cholesterol ozonolysis cause effects that are thought to be critical to the pathogenesis of atherosclerosis, including cytotoxicity, lipid-loading in macrophages, and deformation of the apolipoprotein B-100 secondary structure. We propose the trivial designation "atheronals" for this previously unrecognized class of steroids.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wentworth, Paul Jr -- Nieva, Jorge -- Takeuchi, Cindy -- Galve, Roger -- Wentworth, Anita D -- Dilley, Ralph B -- DeLaria, Giacomo A -- Saven, Alan -- Babior, Bernard M -- Janda, Kim D -- Eschenmoser, Albert -- Lerner, Richard A -- 5T32AI07606/AI/NIAID NIH HHS/ -- GM 43858/GM/NIGMS NIH HHS/ -- P01CA27489/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 2003 Nov 7;302(5647):1053-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Chemistry, The Scripps Research Institute and The Skaggs Institute for Chemical Biology, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/14605372" target="_blank"〉PubMed〈/a〉
Keywords:
Arteriosclerosis/*metabolism
;
Carotid Arteries/*metabolism
;
Cholestanes/blood/*metabolism/pharmacology
;
Cholesterol/*metabolism
;
Dimethyl Sulfoxide/pharmacology
;
Endarterectomy, Carotid
;
Foam Cells/drug effects/physiology
;
Humans
;
Hydrazones/metabolism
;
Indigo Carmine/metabolism
;
Inflammation
;
Leukocytes/metabolism
;
Lipoproteins, LDL/metabolism/pharmacology
;
Norsteroids/blood/*metabolism/pharmacology
;
Oxidation-Reduction
;
Ozone/*metabolism
;
Singlet Oxygen/metabolism
;
Sterols/blood/*metabolism/pharmacology
;
Tetradecanoylphorbol Acetate/pharmacology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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