ISSN:
1573-739X
Keywords:
Chloroquine
;
Citric acid
;
Drug stability
;
Parabens
;
Preservatives, pharmaceutical
;
Sorbic acid
;
Syrup
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract In Third World countries chloroquine phosphate syrup is frequently prepared with chloroform as a preservative. Because of the toxic side effects of chloroform the suitability of a number of possible alternatives were investigated. If the chloroquine phosphate syrup is prepared as such, the combination of sorbic acid (1.5 g/l) and citric acid (2 g/l) is preferred. If, however, the chloroquine phosphate syrup is prepared from a stock solution of simple syrup, the relatively low pH may be undesirable, because it may negatively affect the stability or solubility of other medicinal compounds. For a stock solution of simple syrup the combination of methyl paraben (1.8 g/l) and propyl paraben (0.2 g/l) is preferred. Good care must be taken that a layer of condense water cannot be formed.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01959426
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