Publication Date:
1996-01-19
Description:
In the kindling model of temporal lobe epilepsy, several physiological indicators of inhibition by gamma-aminobutyric acid (GABA) in the hippocampal dentate gyrus are consistent with an augmented, rather than a diminished, inhibition. In brain slices obtained from epileptic (kindled) rats, the excitatory drive onto inhibitory interneurons was increased and was paralleled by a reduction in the presynaptic autoinhibition of GABA release. This augmented inhibition was sensitive to zinc most likely after a molecular reorganization of GABAA receptor subunits. Consequently, during seizures, inhibition by GABA may be diminished by the zinc released from aberrantly sprouted mossy fiber terminals of granule cells, which are found in many experimental models of epilepsy and in human temporal lobe epilepsy.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Buhl, E H -- Otis, T S -- Mody, I -- NS 12151/NS/NINDS NIH HHS/ -- NS 30549/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1996 Jan 19;271(5247):369-73.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Anatomical Neuropharmacology Unit, Oxford University, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8553076" target="_blank"〉PubMed〈/a〉
Keywords:
2-Amino-5-phosphonovalerate/pharmacology
;
6-Cyano-7-nitroquinoxaline-2,3-dione/pharmacology
;
Animals
;
Chlorides/pharmacology
;
Dentate Gyrus/drug effects/*physiology
;
Epilepsy, Temporal Lobe/*physiopathology
;
Excitatory Amino Acid Antagonists/pharmacology
;
GABA-A Receptor Antagonists
;
Humans
;
In Vitro Techniques
;
Interneurons/drug effects/*physiology
;
Kindling, Neurologic/*physiology
;
Male
;
Neural Inhibition/drug effects
;
Pyridines/pharmacology
;
Rats
;
Rats, Wistar
;
Receptors, GABA-A/physiology
;
Receptors, GABA-B/physiology
;
Synaptic Transmission/drug effects
;
Zinc/metabolism/*pharmacology
;
Zinc Compounds/pharmacology
;
gamma-Aminobutyric Acid/*metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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