ISSN:
0947-3440
Schlagwort(e):
Alkaloids
;
Enantiospecific synthesis
;
Chiral building blocks
;
2,5-Disubstituted piperidines
;
(+)-Pseudoconhydrine
;
Chemistry
;
Organic Chemistry
Quelle:
Wiley InterScience Backfile Collection 1832-2000
Thema:
Chemie und Pharmazie
Notizen:
A novel methodology for the synthesis of any one of the four stereoisomers of a 2,5-disubstituted piperidine in optically pure form is described, starting from readily available chiral building blocks 10 and 11 (or their antipodes). The utility of this approach is demonstrated in the total synthesis of (+)-pseudoconhydrine hydrochloride, the structure of which was confirmed by X-ray analysis.
Zusätzliches Material:
1 Ill.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1002/jlac.199719970633
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