ISSN:
1432-1432
Keywords:
Origin of Optical Activity
;
Chiral Crystals
;
Abiotic Asymmetric Synthesis
;
Enantiomorphic
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
Notes:
Summary Many molecules which are achiral can crystallize in chiral (enantiomorphic) crystals and, under suitable conditions, crystals of only one chirality may be obtained. The formation of right- or left- handed crystals in excess is equally probable. Lattice-controlled (topochemical) photochemical or thermal solid-state reactions may then afford stable, optically active products. In the presence of the chiral products, achiral reactants may preferentially produce crystals of one chirality, leading to a feedback mechanism for the generation and amplification of optical activity. Amplification of optical activity can also be achieved by solid-state reactions. The optical synthesis of biologically relevant compounds by such routes may be envisaged.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01732291
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