Publication Date:
2003-09-06
Description:
A novel coronavirus (SCoV) is the etiological agent of severe acute respiratory syndrome (SARS). SCoV-like viruses were isolated from Himalayan palm civets found in a live-animal market in Guangdong, China. Evidence of virus infection was also detected in other animals (including a raccoon dog, Nyctereutes procyonoides) and in humans working at the same market. All the animal isolates retain a 29-nucleotide sequence that is not found in most human isolates. The detection of SCoV-like viruses in small, live wild mammals in a retail market indicates a route of interspecies transmission, although the natural reservoir is not known.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Guan, Y -- Zheng, B J -- He, Y Q -- Liu, X L -- Zhuang, Z X -- Cheung, C L -- Luo, S W -- Li, P H -- Zhang, L J -- Guan, Y J -- Butt, K M -- Wong, K L -- Chan, K W -- Lim, W -- Shortridge, K F -- Yuen, K Y -- Peiris, J S M -- Poon, L L M -- New York, N.Y. -- Science. 2003 Oct 10;302(5643):276-8. Epub 2003 Sep 4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Microbiology, The University of Hong Kong, University Pathology Building, Queen Mary Hospital, Hong Kong Special Administrative Region, People's Republic of China. yguan@hkucc.hku.hk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12958366" target="_blank"〉PubMed〈/a〉
Keywords:
Amino Acid Sequence
;
Animals
;
Animals, Wild/*virology
;
Antibodies, Viral/blood
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Blotting, Western
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Carnivora/*virology
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China
;
Coronavirus/classification/genetics/immunology/*isolation & purification
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Coronavirus Infections/veterinary/virology
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Disease Reservoirs
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Feces/virology
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Genome, Viral
;
Humans
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Membrane Glycoproteins/chemistry/genetics
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Molecular Sequence Data
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Neutralization Tests
;
Nose/virology
;
Open Reading Frames/genetics
;
Phylogeny
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Polymorphism, Genetic
;
Reverse Transcriptase Polymerase Chain Reaction
;
SARS Virus/classification/genetics/immunology/*isolation & purification
;
Sequence Deletion
;
Sequence Homology, Nucleic Acid
;
Spike Glycoprotein, Coronavirus
;
Viral Envelope Proteins/chemistry/genetics
;
Viral Proteins/chemistry/genetics
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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