ISSN:
0018-019X
Keywords:
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Two efficient preparations of the title compound, one from common C19-steroids, the other frm digitoxigenin, are described. The less active minor epimer (21S)-methyldigitoxigenin was also obtained and characterized. The positive inotropic effects and margins of safety of the two C(21)-epimers (tested as glucosides) are discussed in terms of the topological properties of the Digitalis receptors.
Additional Material:
1 Tab.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/hlca.19840670427
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