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  • Chemistry  (7)
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  • 1
    ISSN: 0899-0042
    Keywords: improving enantioselectivity ; lipase ; enantioselective biocatalysis ; enantiomerically pure compounds ; dihydropyridines ; enantioselective inhibition ; cis-3-hydroxy-6-acetoxy-cyclohex-1-ene ; Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Different approaches to improve the enantioselectivity of biocatalytic systems are presented. These methodologies have been successfully applied to the preparation of optically active dihydropyridine, calcium antagonists, and cis-3-hydroxy-6-acetoxy-cyclohex-1-ene, a valuable chiral building block for natural products synthesis. The phenomenon of enantioselective inhibition is described and several new heterocyclic amines have been shown to be effective enantioselective inhibitors in the Candida lipase system.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Zeitschrift für die chemische Industrie 101 (1989), S. 711-724 
    ISSN: 0044-8249
    Keywords: Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Die enantioselektive Biokatalyse in nicht-wäßrigen Medien gewinnt in der präparativen Chemie zunehmend an Bedeutung. Dieser Beitrag beschreibt a) die generellen katalytischen Eigenschaften von Enzymen in nicht-wäßriger Umgebung, b) die grundlegenden Prinzipien der Herstellung optisch aktiver Carbonsäuren und Alkohole durch Lipase-katalysierte enantioselektive Veresterungen und Umesterungen in organischen Medien, c) die Bestimmung kinetischer und thermodynamischer Parameter und d) die quantitative Analyse von veröffentlichten Daten.
    Additional Material: 5 Ill.
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  • 3
    Electronic Resource
    Electronic Resource
    Stamford, Conn. [u.a.] : Wiley-Blackwell
    Polymer Engineering and Science 20 (1980), S. 977-981 
    ISSN: 0032-3888
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: The load carrying capacity of adhesive joints is analyzed by applying the principle of fracture mechanics in which failure is assumed to initiate from sites of initial imperfections such as bubbles, cracks or unbonded portions of the interface. The cohesive and adhesive modes of failure are investigated for a butt joint under angle loading. Based on the prediction of the strain energy density criterion, the lowest failure stress for the adhesive joint occurred when the load is applied at an angle with respect to the crack plane. This is in contrast to the homogeneous material solution where the lowest failure stress corresponds to normal loading. Numerical examples are provided for a joint made of DER 332-TEPA epoxy with aluminum as the adherends. Discussed in detail are the dependencies of the strength of the joint with reference to the material properties of the constituents, geometries of the components, and direction of loading.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 14 (1980), S. 311-324 
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: Polymethyl methacrylate bone cement is tested at the Institute of Fracture and Solid Mechanics Laboratory, Lehigh University. Standard tensile coupon and compact tension specimens are molded under varying conditions of temperature and pressure. Test results are obtained for the strength and toughness of bone cement involved in total hip replacement operations.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Zeitschrift für die chemische Industrie 96 (1984), S. 556-565 
    ISSN: 0044-8249
    Keywords: Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Die mikrobielle asymmetrische Reduktion von Ketonen wird sehr oft zur Herstellung chiraler Alkohole benutzt. Dieser Fortschrittsbericht beschäftigt sich mit den Gesetzmäßigkeiten, die der Enantioselektivität von Enzymen und intakten Zellen zugrundeliegen. Es werden Strategien zur Steuerung des stereochemischen Verlaufs mikrobieller Reduktionen und die Beziehung zwischen Substratstruktur und Enantioselektivität diskutiert.
    Additional Material: 2 Ill.
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  • 6
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Angewandte Chemie International Edition in English 28 (1989), S. 695-707 
    ISSN: 0570-0833
    Keywords: Enantioselectivity ; Lipases ; Synthetic methods ; Enzyme catalysis ; Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Enantioselective biocatalysis in nonaqueous media is becoming increasingly important in preparative synthetic chemistry. This article discusses (1) the general catalytic properties of enzymes in nonaqueous environments, (2) the basic principles that govern lipase-catalyzed enantioselective esterification and transesterification reactions in organic media for the preparation of optically active acids and alcohols, (3) the determination of kinetic and thermodynamic parameters, and (4) the quantitative analysis of published data.
    Additional Material: 5 Ill.
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  • 7
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Angewandte Chemie International Edition in English 23 (1984), S. 570-578 
    ISSN: 0570-0833
    Keywords: Asymmetric catalysis ; Catalysis ; Enantioselectivity ; Reduction ; Ketones ; Synthetic methods ; Biotechnology ; Alcohols ; Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Microbial asymmetric reduction of ketones is a method widely used for the preparation of chiral alcohols. The present progress report deals with the basic concepts that govern enantioselectivity of enzymes and intact cells. Strategies to control the stereochemical course of microbial reductions of carbonyl compounds and the relationship of substrate structure to enantioselectivity are considered.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
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