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  • 1
    Publication Date: 2018-01-26
    Description: The scarcity of complex intermediates in pharmaceutical research motivates the pursuit of reaction optimization protocols on submilligram scales. We report here the development of an automated flow-based synthesis platform, designed from commercially available components, that integrates both rapid nanomole-scale reaction screening and micromole-scale synthesis into a single modular unit. This system was validated by exploring a diverse range of reaction variables in a Suzuki-Miyaura coupling on nanomole scale at elevated temperatures, generating liquid chromatography–mass spectrometry data points for 5760 reactions at a rate of 〉1500 reactions per 24 hours. Through multiple injections of the same segment, the system directly produced micromole quantities of desired material. The optimal conditions were also replicated in traditional flow and batch mode at 50- to 200-milligram scale to provide good to excellent yields.
    Keywords: Chemistry
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Geosciences , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 2
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 14 (1970), S. 17-34 
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Theoretical solutions for unsteady flow of a three constant Oldroyd fluid and a second order fluid under several different flow conditions of practical interest are obtained. The response of these fluids to suddenly applied external force is investigated in each case. Without using the stick-slip boundary condition at the wall, it is possible to show that pressure oscillation occurs with both fluids under a certain case.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 15 (1971), S. 369-379 
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: The creeping flow of a highly viscous incompressible fluid through a circular aperture located in an infinitely wide horizontal plate is analyzed by solving Navier-Stokes equations without inertia terms. Solutions for vertical and radial velocities as well as pressure have been obtained in terms of integral equations with an undetermined Kernal function. This function has been evaluated by assuming several different velocity distributions at the aperture, and the corresponding pressure drop for each case has been calculated. The results show that the pressure loss for a given flow rate goes through a minimum as the assumed velocity profile changes from flat to parabolic. Based on the minimum energy dissipation theorem of Helmholtz, the most appropriate velocity distribution is discussed. Experimental data obtained using sharp-edged orifices are compared with theoretical predictions.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 14 (1970), S. 1639-1650 
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Transient flow behavior of an incompressible quasi-linear viscoelastic fluid under suddenly applied constant pressure as well as under a periodic pressure gradient was investigated using a three-parameter relaxation function. In the light of these solutions, the roll of viscoelastic relaxation in the overshooting of volumetric flow rate and the effect of viscoelastic parameters on the mean square velocity profile are discussed.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 13 (1969), S. 241-247 
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Based on a simple, general kinetic scheme for the inhibition reaction of a photopoly-merizing system, a solution is obtained for the differential equation which describes the oxygen concentration profile as a function of exposure time, light intensity, and absorption coefficient. The effect of the absorption coefficient on the oxygen concentration in a polymer slab is evaluated by numerical computation.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 12 (1968), S. 191-212 
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: A general equation for the true shear rate encountered in calendering non-Newtonian fluids is derived. Based on several constitutive equations (for a power-law, a three-constant Oldroyd, and a modified second-order Rivlin-Ericksen fluid), calendering is analyzed from the hydrodynamic point of view. The significance of dimensionless groups (the Deborah number, the Weisenberg numbers, and the viscoelastic ratio number), consisting of rheological and kinematic parameters, is discussed for scaling from prototype to production calendering. Correlation of experimental data obtained by using laboratory and production calenders is presented, and the scaling criteria obtained from the theory are examined. The onset of unstable flow, which causes non-uniform internal strain patterns (nerve) in calendered sheeting, is discussed in terms of the Weisenberg number. Good and poor calendering regions for a polymer are discussed qualitatively by using a dynamic response diagram, and the importance of the overall calendering conditions on the final sheeting quality is discussed.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 15 (1971), S. 2007-2021 
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: The dependence of the viscosities of highly concentrated suspensions on solids concentrations and particle size distributions is investigated by using an orifice viscometer. Based on the extensive amount of data on pertinent systems, an empirical equation which correlates the relative viscosities of suspensions (or relative moduli of filled polymeric materials) as a function of solids concentrations and particle size distributions is proposed. The equation has a constant which characterizes size distributions of spherical particles and can be determined experimentally without measuring viscosities. For uniform-size spherical particles, it reduces to the well-known Einstein equation at dilute solids concentrations.
    Additional Material: 12 Ill.
    Type of Medium: Electronic Resource
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