ISSN:
0018-019X
Keywords:
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The syntheses and biological activities of 4 analogues of the thyrotropin-releasing hormone (TRH) are described. In these analogues the histidine residue has been replaced by L-lysine, L-α,γ-diaminobutyric acid, β-(3-pyrazolyl)-L-alanine, and L-arginine. All analogues exhibited the characteristic biological responses of TRH. For the β-(3-pyrazolyl)-L-alanine analogue as well as for TRH the bioassays suggest an induction of a strong and rapid resynthesis of thyrotropin (TSH) in higher (μg) concentrations.
Additional Material:
2 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/hlca.19710540513
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